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        • Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 {"id":70,"date":"2013-03-09T20:57:42","date_gmt":"2013-03-09T19:57:42","guid":{"rendered":"http:\/\/signalife.unice.fr\/"},"modified":"2020-07-09T14:09:58","modified_gmt":"2020-07-09T13:09:58","slug":"institutes-axes-group-leaders","status":"publish","type":"page","link":"https:\/\/signalife.univ-cotedazur.fr\/?page_id=70","title":{"rendered":"Institutes and Axes"},"content":{"rendered":"
        \n
        \n

        Research Institutes<\/h1>\n
        <\/div>\n
        \n
        <\/div>\n<\/div>\n
        <\/div>\n
        \n
        <\/div>\n
        \n

        SIGNALIFE<\/h2>\n

        Network for Innovation on Signal Transduction Pathways in Life Sciences<\/h3>\n<\/div>\n<\/div>\n
        \n
        \n

        Partner 1<\/strong><\/p>\n

        iBV<\/a><\/h2>\n

        Institut de Biologie Valrose<\/p>\n

        <\/div>\n

        \"\"<\/a><\/p>\n<\/div>\n

        \n

        Partner 2<\/strong><\/p>\n

        IPMC<\/a><\/h2>\n

        Institut de Pharmacologie Mol\u00e9culaire et Cellulaire<\/p>\n

        \"\"<\/a><\/p>\n<\/div>\n

        \n

        Partner 3<\/strong><\/p>\n

        C3M<\/a><\/h2>\n

        Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire<\/p>\n

        \"\"<\/a><\/p>\n<\/div>\n

        \n

        Partner 4<\/strong><\/p>\n

        IRCAN<\/a><\/h2>\n

        Institute for Research on Cancer and Aging of Nice<\/p>\n

        \"\"<\/a><\/p>\n<\/div>\n

        \n

        Partner 5<\/strong><\/p>\n

        ISA<\/a><\/h2>\n

        Institut Sophia Agrobiotech<\/p>\n

        <\/div>\n

        \"\"<\/a><\/p>\n<\/div>\n

        \n

        Partner 6<\/strong><\/p>\n

        INRIA<\/a><\/h2>\n

        Sophia Antipolis-M\u00e9diterran\u00e9en Research Centre<\/p>\n

        \"\"<\/a><\/p>\n<\/div>\n<\/div>\n

        <\/div>\n

        Our goal for the next eight years is to reinforce our leadership on model Signaling Pathways (SP) and processes studied by SIGNALIFE partners, gain a deeper understanding of their organization and function, identify new frontiers and concepts, altogether contributing to the building of an innovative campus of excellence on signaling<\/b>.<\/p>\n

         <\/p>\n

        Research Axes<\/h1>\n

        5 Research Axes <\/strong><\/p>\n

        The SIGNALIFE project is organized into 5 main axes<\/b>, building on existing research expertise and collaborative work from partners to address specific questions, as follows:<\/p>\n

        1 \u2018Cellular architecture of signaling pathways\u2019:<\/strong>
        \nWe will explore the structure, organization, compartmentalization and function of major model SP studied by partners. Genetic, proteomic and biochemical screens will be used for new component discovery.<\/p>\n

        2 \u2018Plasticity and Signaling\u2019:<\/strong>
        \nUsing a range of model systems, we will explore the molecular mechanisms underlying cell plasticity through biological SP involved in stem and reprogrammed cells.<\/p>\n

        3 \u2018Stress Signaling\u2019:<\/strong>
        \nCells and organisms respond to various internal and external stresses. We will explore the dynamics of a range of stress signals and their impact on cells, tissues and organisms through modifications of various SP.<\/p>\n

        4 \u2018Signaling in aging and disease progression\u2019:<\/strong>
        \nWe will explore the molecular mechanisms leading to SP dysfunction during aging and in a range of pathologies including cancer, neurological, metabolic and inflammatory disorders.<\/p>\n

        5 \u2018New principles in signaling and applications\u2019:<\/strong>
        \nIn this transversal axis, we will set up conditions for maximal data\/ideas sharing between all participants and develop modeling with the aim of making new hypotheses and concepts leading to innovative projects and large scale cross-platform srceens.<\/p>\n<\/div>\n

         <\/p>\n

        <\/div>\n
        \n
        <\/div>\n<\/div>\n
        <\/div>\n

        Institutions<\/h2>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        \"\"<\/a><\/div>\n
        <\/div>\n\n<\/div> ","protected":false},"excerpt":{"rendered":"

        Research Institutes Partner 1 iBV Institut de Biologie Valrose Partner 2 IPMC Institut de Pharmacologie Mol\u00e9culaire et Cellulaire Partner 3 C3M Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire Partner 4 IRCAN Institute for Research on Cancer and Aging of Nice Partner 5 ISA Institut Sophia Agrobiotech Partner 6 INRIA Sophia Antipolis-M\u00e9diterran\u00e9en Research Centre Our goal for the next eight years is to reinforce our leadership on model Signaling Pathways (SP) and processes studied by SIGNALIFE partners, gain a deeper understanding of their organization and function, identify new frontiers and concepts, altogether contributing to the building of an innovative campus of excellence on signaling.   Research Axes 5 Research Axes The SIGNALIFE project is organized into 5 main axes, building on existing research expertise and collaborative work from partners to address specific questions, as follows: 1 \u2018Cellular architecture of signaling pathways\u2019: We will explore the structure, organization, compartmentalization and function of major model SP studied by partners. Genetic, proteomic and biochemical screens will be used for new component discovery. 2 \u2018Plasticity and Signaling\u2019: Using a range of model systems, we will explore the molecular mechanisms underlying cell plasticity through biological SP involved in stem and reprogrammed cells. 3 \u2018Stress Signaling\u2019: Cells and organisms respond to various internal and external stresses. We will explore the dynamics of a range of stress signals and their impact on cells, tissues and organisms through modifications of various SP. 4 \u2018Signaling in aging and disease progression\u2019: We will explore the molecular mechanisms leading to SP dysfunction during aging and in a range of pathologies including cancer, neurological, metabolic and inflammatory disorders. 5 \u2018New principles in signaling and applications\u2019: In this transversal axis, we will set up conditions for maximal data\/ideas sharing between all participants and develop modeling with the aim of making new hypotheses and concepts leading to innovative projects and large scale cross-platform srceens.   Institutions<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/70"}],"collection":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=70"}],"version-history":[{"count":134,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/70\/revisions"}],"predecessor-version":[{"id":7894,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/70\/revisions\/7894"}],"up":[{"embeddable":true,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=70"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}