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- Flow Cytometry Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 Warning: Cannot modify header information - headers already sent by (output started at /volume2/web/signalife/index.php:1) in /volume2/web/signalife/wp-includes/rest-api/class-wp-rest-server.php on line 1372 {"id":5249,"date":"2017-06-06T10:05:10","date_gmt":"2017-06-06T09:05:10","guid":{"rendered":"http:\/\/signalife.unice.fr\/?page_id=5249"},"modified":"2017-12-08T16:10:30","modified_gmt":"2017-12-08T15:10:30","slug":"in-the-spotlight-2017","status":"publish","type":"page","link":"https:\/\/signalife.univ-cotedazur.fr\/?page_id=5249","title":{"rendered":"In the Spotlight 2017"},"content":{"rendered":"
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Labex PhD Student Prize<\/h2>\n
\nHighlight on Rania Ben Jouira’s ARC Foundation Prize <\/strong><\/p>\n
<\/a><\/p>\n
Rania Ben Jouira, 2013 Labex PhD Student. Team Sophie Tartare Deckert, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M). PhD project title : Microenvironment, signaling and cancer.
\nPress : Nice-Matin
\nYoung Researcher ARC Foundation Prize (Association pour la Recherche sur le Cancer), H\u00e9l\u00e8ne Starck Prize : Jury Prize to Rania Ben Jouira, for her oral presentation \u00ab Extracellular matrix produced by BRAF inhibitor-resistant melanoma cells promotes therapeutic resistance to drug-sensitive cells \u00bb<\/p>\nPress release<\/a><\/p>\n
On Thursday, November, 16, and Friday, November 17, 2017, were held the ARC Foundation’s 21st Young Researchers Days. Nearly 200 participants, including more than 100 young researchers, contributed to this event. These days presented the perfect opportunity for the numerous and rich exchanges on the different fields of research in oncology.<\/p>\n
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Related links:<\/p>\n
Webtimemedias<\/a>
\n20minutes<\/a>
\nPressreader<\/a>
\nNice-Matin<\/a>\n<\/div>\n<\/li>\n- \n
2017 Labex Publication<\/h2>\n
\nHighlight on one 2017 Labex Publication<\/strong><\/p>\n
Yue JX, Li J, Aigrain L, Hallin J, Persson K, Oliver K, Bergstr\u00f6m A, Coupland P, Warringer J, Lagomarsino MC, Fischer G, Durbin R,\u00a0Liti G<\/strong>
\nNat Genet. 2017 Apr 17. doi: 10.1038\/ng.3847. [Epub ahead of print]
\nPMID: 28416820
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28416820<\/a>
\nImpact Factor: 31.6
\nTeam Gianni LITI \u00ab Population genomics and complex traits \u00bb<\/strong><\/p>\n<\/a><\/p>\n
French media<\/p>\n
http:\/\/www.cnrs.fr\/insb\/recherche\/parutions\/articles2016\/g-liti.html<\/a><\/p>\n
Nat Genet.<\/a> 2017 Jun;49(6):913-924. doi: 10.1038\/ng.3847. Epub 2017 Apr 17<\/p>\n
New sequencing tools give up close look at yeast evolution<\/strong><\/p>\n
Ever\u00a0since the Austrian monk Gregor Mendel’s famous pea plant experiment 150 years\u00a0ago, scientists have embarked a century-long endeavor to illuminate\u00a0how the\u00a0genetic information encoded in our DNAs gets translated into the vast diversity\u00a0of phenotypes — the physical expression of our genetic\u00a0information. Thanks to\u00a0the rapid progress of DNA sequencing technology, we can now easily sequence our\u00a0DNAs by chopping it into millions of small pieces\u00a0and sequencing them at\u00a0massive scale. However, to place back those sequenced small pieces is no easy\u00a0task, much like solving a jigsaw puzzle\u00a0with missing pieces and several pieces that can fit\u00a0at\u00a0the same place. In particular, there are many regions along our DNAs\u00a0enriched with complex structural rearrangements that are\u00a0difficult to resolve using\u00a0short-read sequencing technology. As a result, many such complex regions still\u00a0remain as black boxes,\u00a0despite accumulating evidence suggesting their important\u00a0implications in adaptation and disease susceptibility.<\/p>\n
The\u00a0recent advent of long-read sequencing technology has proven to be quite\u00a0powerful in producing complete genome assemblies with many complex\u00a0regions\u00a0correctly resolved for a single reference genome. Here, an international\u00a0consortium led by Jia-Xing Yue and Gianni Liti took this to the next level.\u00a0They sequenced 12 representative strains from the partially domesticated baker\u2019s\u00a0yeast (Saccharomyces cerevisiae) and\u00a0its closest wild relative (Saccharomyces\u00a0paradoxus) to generate the first set of population-level\u00a0end-to-end genome\u00a0assemblies. By systematically comparing these complete genome sequences both\u00a0within and between species,\u00a0they were able to accurately capture structural\u00a0genome dynamics along the evolutionary history of these two species and\u00a0revealed\u00a0the striking contrasts between them, many of which likely explained by\u00a0the intimate association between the baker\u2019s yeast and\u00a0human activities. Moreover,\u00a0the regions locate near the two ends of chromosomes (known as \u201csubtelomeres\u201d) are\u00a0evolving very fast\u00a0with frequent structural rearrangements. This study provided\u00a0the first accurate definition for these regions and illuminated their\u00a0excessive\u00a0evolutionary dynamics with unprecedented resolution. Finally, they further exemplified\u00a0how the fully resolved structural\u00a0rearrangements in those complex regions could\u00a0help to illuminate complex traits. All the high-quality genome assemblies and\u00a0annotations generated by this study are shared to the public\u00a0and the scientific community,\u00a0which will serve as population-level\u00a0reference genomes to guide future genomic\u00a0and functional studies. This study represents another milestone in eukaryotic\u00a0genomics\u00a0and will pave the road towards a better understanding of\u00a0genotype-phenotype relationship. Human cancer cells are also known for\u00a0elevated\u00a0structural rearrangements and genome reshuffling. As the next step, this\u00a0consortium is planning to apply long-read\u00a0sequencing technology to human tumor\u00a0tissues to pinpoint the genetic drivers of genome instability, which may reveal\u00a0new targets\u00a0for anti-cancer drug development.<\/p>\n
PMID:28416820PMCID:PMC5446901<\/a>[Available on 2017-10-17]DOI:10.1038\/ng.3847<\/a>\n<\/div>\n<\/li>\n<\/ul>\n\n<\/div> ","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/5249"}],"collection":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5249"}],"version-history":[{"count":13,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/5249\/revisions"}],"predecessor-version":[{"id":5808,"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=\/wp\/v2\/pages\/5249\/revisions\/5808"}],"wp:attachment":[{"href":"https:\/\/signalife.univ-cotedazur.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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